In Deadpool #54, the Merc With A Mouth revealed a brand new look which is sure to upset longtime fans of the character. You see, Wade Wilson is now...handsome! After being injected with a serum which negated his healing powers and made him mortal, the final instalment of "Dead" reveals that the assassin has also been cured of the cancer which left him hideously scarred. Here's a scan from the issue (courtesy of Fangirling Daily) that reveals a new appearance which is sure to have a huge impact on the future of the character.
And below is how Wade Wilson/Deadpool used to look before the big change.